The role of cinnamon as an antioxidant in treating Polycystic Ovary Syndrome in humans and laboratory animals: A review
Cinnamon against PCOS
DOI:
https://doi.org/10.62310/liab.v5i1.201Keywords:
Polycystic ovary syndrome, Rodents, Insulin, Cinnamon, Hormones, DiabetesAbstract
Hormonal derangements, abnormal menstrual patterns, and metabolic impairment are the characteristics of polycystic ovary syndrome (PCOS). It is a frequent endocrine disease among both women and certain small animals. PCOS is associated with oxidative stress, obesity, insulin resistance, and hyperandrogenism, all of which contribute to the complex pathogenesis of the syndrome. Due to the complex procedures of traditional treatment for PCOS by using pharmacologic treatment, surgery like bariatric surgery, and lifestyle modifications, scientists have diverted their attention towards alternatives. An easily available spice, cinnamon has been found to have promising findings in preclinical and clinical trials. Cinnamon extracts have been found to decrease blood pressure, increase insulin sensitivity, alter hormone levels, and reduce oxidative stress in small animals. Several mechanisms, including AMPK (AMP-activated protein kinase) activation, modulation of the insulin signaling pathway, and regulation of key transcription factors are responsible for these effects. Supplementation with cinnamon has been determined through clinical trials to assist patients with their weight control, regulation of their menstrual cycle, and improving insulin sensitivity. This review examines the potential therapeutic application of cinnamon in the treatment of PCOS, examining its effects both in humans and laboratory animals. The present analysis captures cinnamon's role as a treatment supplemental agent through the integration of all data on its multiple benefits in treating the various aspects of PCOS. To fully comprehend the action mechanisms and optimize its therapeutic application to PCOS management, further research is required.
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Copyright (c) 2025 Amisha Naz, Muhammad Zeeshan Haider Javed, Alina Farooq, Amaila Noor, Aqsa Shafique, Shahzar Umar , Muhammad Umar Suleman, Insharah Insharah, Arslan Muhammad Ali Khan, Muhammad Usama Javed
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2025-04-26
Published 2025-04-29
